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Below is a growing list of references concerning the evolution of the genetic code. References are listed alphabetically by author, but you can search the references by author, title, keyword, or categoy by using the Search References form on the left. If you have a publication that you would like to add or remove from the list, please use our Request to Add or Remove a Reference form. To view publications from the Freeland Lab, please visit our Publications page.

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  1. Akashi H., "Codon bias evolution in Drosophila. Population genetics of mutation-selection drift," Gene, vol. 205, pp. 269-78, 1997. [Link] [Edit]
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  3. Akashi, H., and T. Gojobori., " Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis.," Proc Natl Acad Sci U S A, vol. 99, pp. 3695-700., 2002. [Link] [Edit]
  4. ALesbians, "DLesbians," Bioinformatics, vol. 0, pp. http://lesbian.2hp.e, 2005. [Link] [Edit]
  5. Alexey G. Murzin, Steven E. Brenner, Tim Hubbard and Cyrus Chothia, "SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures," J. Mol. Biol., vol. 247, pp. 536–540, 1995. [Link] [Edit]
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  11. Amirnovin, R., "An analysis of the metabolic theory of the origin of the genetic code.," J Mol Evol, vol. 44, pp. 473-476, 1997. [Link] [Edit]
  12. Andreeva A, Howorth D, Brenner SE, Hubbard TJ, Chothia C, Murzin AG., "SCOP database in 2004: refinements integrate structure and sequence family data.," Nucleic Acids Res, vol. 32, pp. D226-D229, 2004. [Link] [Edit]
  13. Apostol, I., Levine, J., Lippincott, J., Leach, J., Hess, E., Glascock, C.B., Weickert, M.J. and Blackmore, R., "Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli.," J Biol Chem, vol. 272, pp. 28980-28988, 1997. [Link] [Edit]
  14. Atkins, J.F. and Gesteland, R., "Biochemistry. The 22nd amino acid.," Science, vol. 296, pp. 1409-1410, 2002. [Link] [Edit]
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  16. Bada, J.L., Glavin, D.P., McDonald, G.D. and Becker, L., "A search for endogenous amino acids in martian meteorite ALH84001.," Science, vol. 279, pp. 362-365, 1998. [Link] [Edit]
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  18. Baumann U, Oro J., "Three stages in the evolution of the genetic code," Biosystems, vol. 29, pp. 133-41, 1993. [Link] [Edit]
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  20. Benner SA, Cohen MA, Gonnet GH, "Amino acid substitution during functionally constrained divergent evolution of protein sequences," Protein Eng., vol. 7, pp. 1323-32, 1994. [Link] [Edit]
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  23. Boycheva, S., G. Chkodrov, and I. Ivanov, "Codon pairs in the genome of Escherichia coli," Bioinformatics, vol. 19, pp. 987-98, 2003. [Link] [Edit]
  24. Buckingham RH., "Codon context," Experientia., vol. 46, pp. 1126-33, 1990. [Link] [Edit]
  25. Budisa, N., Minks, C., Medrano, F.J., Lutz, J., Huber, R. and Moroder, L., "Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V.," Proc Natl Acad Sci U S A, vol. 95, pp. 455-459, 1998. [Link] [Edit]
  26. Bulmer, M., "Coevolution of codon usage and transfer RNA abundance," Nature, vol. 325, pp. 728-30, 1987. [Link] [Edit]
  27. Bulmer, M., "The selection-mutation-drift theory of synonymous codon usage," Genetics, vol. 129, pp. 897-907, 1991. [Link] [Edit]
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  29. Chang MS, Benner SA, "Empirical analysis of protein insertions and deletions determining parameters for the correct placement of gaps in protein sequence alignments," J Mol Biol, vol. 341, pp. 617-631, 2004. [Link] [Edit]
  30. Chyba, C. and Sagan, C., "Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life," Nature, vol. 355, pp. 125-132, 1992. [Link] [Edit]
  31. CLesbians, "ELesbians," Nucleic Acids Symposium Series, vol. 33, pp. http://lesbian.2hp.e, 1995. [Link] [Edit]
  32. Coghlan, A., and K. H. Wolfe, "Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae," Yeast, vol. 16, pp. 1131-45, 2000. [Link] [Edit]
  33. Crick, F. H. C., "The structure of nucleic acids and their role in protein synthesis.," Biochem. Soc. Symp., vol. 14, pp. 25 - 26, 1957. [Link] [Edit]
  34. Cronin, J.R. and Pizzarello, S., "Enantiomeric excesses in meteoritic amino acids.," Science, vol. 275, pp. 951-955, 1997. [Link] [Edit]
  35. Cropp, T.A. and Schultz, P.G., "An expanding genetic code," Trends Genet, vol. 20, pp. 625-630, 2004. [Link] [Edit]
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  37. Dayhoff MO, Schwartz RM, Orcutt BC: A model of evolutionary change in proteins. In Atlas of Protein Science and Structure. Edited by Dayhoff MO. National Biomedical Research Foundation; 1978. [Link] [Edit]
  38. Desper R, Gascuel O, "Fast and accurate phylogeny reconstruction algorithms based on the minimum-evolution principle," J Comp Biol, vol. 9, pp. 687-705, 2002. [Link] [Edit]
  39. Dillon, L.S., "The origins of the genetic code.," Bot. Rev., vol. 39, pp. 301-345, 1973. [Link] [Edit]
  40. Do CB, Mahabhashyam MS, Brudno M, Batzoglou S, "ProbCons: Probabilistic consistency-based multiple sequence alignment," Genome Res, vol. 15, pp. 330-340, 2005. [Link] [Edit]
  41. dos Reis, M., L. Wernisch, and R. Savva, "Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genome," Nucleic Acids Res, vol. 31, pp. 6976-85, 2003. [Link] [Edit]
  42. Duret L., " Evolution of synonymous codon usage in metazoans," Curr Opin Genet Dev., vol. 12, pp. 640-9, 2002. [Link] [Edit]
  43. Duret, L., "tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes," Trends Genet, vol. 16, pp. 287-9, 2000. [Link] [Edit]
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  45. Edgar RC, "MUSCLE: a multiple sequence alignment method with reduced time and space complexity," BMC Bioinformatics, vol. 5, pp. 113, 2004. [Link] [Edit]
  46. Eigen, M. and Schuster, P., "The hypercycle. A principle of natural self-organization. Part C: the realistic hypercycle.," Naturwissenschaften, vol. 65, pp. 341-369, 1978. [Link] [Edit]
  47. Ermolaeva MD., "Synonymous codon usage in bacteria," Curr Issues Mol Biol., vol. 3, pp. 91-7, 2001. [Link] [Edit]
  48. Eyre-Walker, A., "Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy?," Mol Biol Evol, vol. 13, pp. 864-72, 1996. [Link] [Edit]
  49. Eyre-Walker, A., and M. Bulmer, "Reduced synonymous substitution rate at the start of enterobacterial genes," Nucleic Acids Res, vol. 21, pp. 4599-603, 1993. [Link] [Edit]
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  51. Fox, S.W., "Thermal synthesis of amino acids and the origin of life.," Geochim Cosmochim Acta, vol. 59, pp. 1213-1214, 1995. [Link] [Edit]
  52. Fuglsang, A., "Codon optimizer: a freeware tool for codon optimization," Protein Expr Purif, vol. 31, pp. 247-9, 2003. [Link] [Edit]
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  54. Gamow, G., "Possible relation between deoxyribonucleic acid and protein structure.," Nature, vol. 173, pp. 318, 1954. [Link] [Edit]
  55. Gao, W., A. Rzewski, H. Sun, P. D. Robbins, and A. Gambotto, "UpGene: Application of a web-based DNA codon optimization algorithm," Biotechnol Prog, vol. 20, pp. 443-8, 2004. [Link] [Edit]
  56. Gilbert, W., "Origin of life: The RNA world.," Nature, vol. 319, pp. 618, 1986. [Link] [Edit]
  57. Gouy, M., and C. Gautier, "Codon usage in bacteria: correlation with gene expressivity," Nucleic Acids Res, vol. 10, pp. 7055-74, 1982. [Link] [Edit]
  58. Grantham, R., C. Gautier, M. Gouy, M. Jacobzone, and R. Mercier, "Codon catalog usage is a genome strategy modulated for gene expressivity," Nucleic Acids Res, vol. 9, pp. r43-74, 1981. [Link] [Edit]
  59. Grosjean, H., and W. Fiers, "Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes," Gene, vol. 18, pp. 199-209, 1982. [Link] [Edit]
  60. Gu X, Li WH, "The size distribution of insertions and deletions in human and rodent pseudogenes suggests the logarithmic gap penalty for sequence alignment," J Mol Evol, vol. 40, pp. 464-473, 1995. [Link] [Edit]
  61. Gygi, S. P., Y. Rochon, B. R. Franza, and R. Aebersold, "Correlation between protein and mRNA abundance in yeast," Mol Cell Biol, vol. 19, pp. 1720-30, 1999. [Link] [Edit]
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  63. Hartman, H., "Speculations on the origin of the genetic code.," J Mol Evol, vol. 40, pp. 541-544, 1995. [Link] [Edit]
  64. Hayes, "The invention of the genetic code," American Scientist, vol. 86, pp. 8-14, 1998. [Link] [Edit]
  65. Henikoff S, Henikoff JG, "Performance evaluation of amino acid substitution matrices," Proteins, vol. 17, pp. 49-61, 1993. [Link] [Edit]
  66. Henikoff, S. and Henikoff, J.G., "Amino acid substitution matrices from protein blocks.," Proc Natl Acad Sci U S A, vol. 89, pp. 10915-10919, 1992. [Link] [Edit]
  67. Holm, L., "Codon usage and gene expression," Nucleic Acids Res, vol. 14, pp. 3075-87, 1986. [Link] [Edit]
  68. Hoover, D. M., and J. Lubkowski, "DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis," Nucleic Acids Res, vol. 30, pp. e43, 2002. [Link] [Edit]
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  70. Ikemura, T., "Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system," J Mol Biol, vol. 151, pp. 389-409, 1981. [Link] [Edit]
  71. Ikemura, T., "Correlation between the abundance of yeast transfer RNAs and the occurrence of the respective codons in protein genes. Differences in synonymous codon choice patterns of yeast and Escherichia coli with reference to the abundance of isoaccepting transfer R," J Mol Biol, vol. 158, pp. 573-97, 1982. [Link] [Edit]
  72. Ikemura, T., "Codon usage and tRNA content in unicellular and multicellular organisms," Mol Biol Evol, vol. 2, pp. 13-34, 1985. [Link] [Edit]
  73. Irvine, W.M., "Extraterrestrial organic matter: a review," Orig Life Evol Biosph, vol. 28, pp. 365-383, 1998. [Link] [Edit]
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  75. Jansen, R., H. J. Bussemaker, and M. Gerstein, "Revisiting the codon adaptation index from a whole-genome perspective: analyzing the relationship between gene expression and codon occurrence in yeast using a variety of models," Nucleic Acids Res, vol. 31, pp. 2242-51, 2003. [Link] [Edit]
  76. Jukes TH, Osawa S, Muto A, Lehman N, "Evolution of anticodons: Variations in the genetic code," Cold Spring Harbor Symposia in Quantitative Biology, vol. 52, pp. 769-776, 1978. [Link] [Edit]
  77. Jukes, T.H., "Arginine as an evolutionary intruder into protein synthesis.," Biochem Biophys Res Commun, vol. 53, pp. 709-714, 1973. [Link] [Edit]
  78. Jungck, J. R., "The genetic code as a periodic table," J Mol Evol, vol. 11, pp. 211-224, 1978. [Link] [Edit]
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  80. Kahsay R, Wang G, Dongre N, Gao G, Dunbrack RL, ": CASA: A server for the critical assessment of protein sequence alignment accuracy," Bioinformatics, vol. 18, pp. 496-497, 2002. [Link] [Edit]
  81. Kane, J. F., "Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli," Curr Opin Biotechnol, vol. 6, pp. 494-500, 1995. [Link] [Edit]
  82. Karlin, S. and S. F. Altschul, "Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes," Proc Natl Acad Sci, vol. 87, pp. 2264-2268, 1990. [Link] [Edit]
  83. Keefe, A.D., Miller, S.L., McDonald, G. and Bada, J., "Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent.," Proc Natl Acad Sci U S A, vol. 92, pp. 11904-11906, 1995. [Link] [Edit]
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  85. Knight, R. and Yarus, M., "Finding specific RNA motifs: function in a zeptomole world?," Rna, vol. 9, pp. 218-230, 2003. [Link] [Edit]
  86. Knight, R. D., S. J. Freeland, and L. F. Landweber, "A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes," Genome Biol, vol. 2, pp. RESEARCH0010, 2001. [Link] [Edit]
  87. Knight, R. D., S. J. Freeland, and L. F. Landweber, "Rewiring the keyboard: evolvability of the genetic code," Nat Rev Genet 2, vol. 2, pp. 49-58, 2001. [Link] [Edit]
  88. Knight, R.D., Freeland, S.J. and Landweber, L.F., "Rewiring the keyboard: evolvability of the genetic code.," Nat Rev Genet, vol. 2, pp. 49-58, 2001. [Link] [Edit]
  89. Kuan, Y.-J., Charnley, S.B. Huang, H-C, Tseng, W-L, and Kisiel, Z., "Interstellar glycine.," Astrophys. J., vol. 593, pp. 848-867, 2003. [Link] [Edit]
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  93. Lee, D. H., Severin, K., Yokobayashi, Y. & Ghadiri, M. R., "Emergence of symbiosis in peptide self-replication through a hypercyclic network," Nature, vol. 390, pp. 591-594, 1997. [Link] [Edit]
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  99. McClure MA, Vasi TK, Fitch WM, "Comparative analysis of multiple protein-sequence alignment methods," Mol Biol Evol, vol. 11, pp. 571-592, 1994. [Link] [Edit]
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  101. Nakamura, Y., T. Gojobori, and T. Ikemura., "Codon usage tabulated from the international DNA sequence databases; its status 1999," Nucleic Acids Res, vol. 27, pp. 292, 1999. [Link] [Edit]
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  108. Raghava GPS, Searle SMJ, Audley P, Barber JD, Barton GJ, "OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy," BMC Bioinformatics, vol. 4, pp. 47, 2003. [Link] [Edit]
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  114. S. Sengupta, P.G. Higgs, "A unified model of codon reassignment in alternative genetic codes," Genetics, vol. 170, pp. 831-840, 2005. [Link] [Edit]
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